Positive Samples: Jurkat; Cellular Location: Cytoplasm, Nucleus, gem
This gene encodes one of the proteins found in the SMN complex, which consists of the suvival of motor neuron protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.
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Protein Aliases: Component of gems 2; gem (nuclear organelle) associated protein 2; Gem-associated protein 2; Gemin-2; SMN interacting protein 1-delta; SMN interacting protein-1; SMN-interacting protein 1; survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1; survivor of motor neuron protein interacting protein 1
Gene Aliases: 1700012N19Rik; GEMIN2; SIP1; SIP1-delta