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Alomone Labs, LTD
Gephyrin Polyclonal Antibody
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FIGURE: 1 / 2
Gephyrin Antibody (AIP-005-GP-200UL) in IHC (F)
Expression of Gephyrin in rat hippocampus Immunohistochemical staining of perfusion-fixed frozen rat brain sections with Guinea Pig Anti-Gephyrin Antibody (#AIP-005-GP) (1:1000), followed by donkey anti-guinea pig-biotin and Streptavidin-Cy3. A. Gephyrin showed immunoreactivity (red) in the mossy fiber terminal zone (MFT, arrow) and in the pyramidal layer of the CA3 region (CA3). B. Pre-incubation of the an... View More
Product Details
AIP-005-GP-200UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Guinea pig
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide DNFNVLPDTKERFYAS, corresponding to amino acid residues 297-312 of mouse NPSR1. Extracellular, 3rd loop.
Conjugate
Form
Lyophilized
Concentration
0.8 mg/mL
Amount
160 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.4, with 1% BSA
Contains
0.05% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Immunogen sequence: DNFNVLPDTKERFYAS
Reconstitution: 25 uL, 50 uL or 0.2 mL double distilled water (DDW), depending on the sample size. The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20C. The reconstituted solution can be stored at 4C for up to 1 week. For longer periods, small aliquots should be stored at -20C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).
Target Information
Gephyrin is a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Gephyrin; gephyrin isoform; Putative glycine receptor-tubulin linker protein; unnamed protein product
Gene Aliases: 5730552E08Rik; AI662856; BC027112; C230040D23; GEPH; GPH; GPHN; GPHRYN; HKPX1; KIAA1385; MOCODC
UniProt ID: (Human) Q9NQX3, (Rat) Q03555, (Mouse) Q8BUV3
Entrez Gene ID: (Human) 10243, (Rat) 64845, (Mouse) 268566
nucleotide binding
catalytic activity
receptor binding
protein binding
ATP binding
nitrate reductase activity
transferase activity
protein binding, bridging
identical protein binding
molybdopterin cofactor binding
metal ion binding
binding, bridging
molybdopterin adenylyltransferase activity
molybdopterin molybdotransferase activity
tubulin binding
protein complex scaffold
protein homodimerization activity
cytoskeletal protein binding
Mo-molybdopterin cofactor biosynthetic process
synapse assembly
establishment of synaptic specificity at neuromuscular junction
response to metal ion
molybdopterin cofactor biosynthetic process
establishment of protein localization
synapse organization
synaptic transmission, GABAergic
glycine receptor clustering
protein localization to membrane
gamma-aminobutyric acid receptor clustering
neurotransmitter receptor localization to postsynaptic specialization membrane
protein targeting
molybdenum incorporation into molybdenum-molybdopterin complex
protein homooligomerization
metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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