This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%).
This antibody has specificity for Human GRID2.
Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamategated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven structurally related subunits, designated GluR-1 to -7, as well as GluR- delta2. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate whereas the NMDA receptors are functionally characterized by a slow kinetic and a high permeability for Ca2+ ions. The NMDA receptors consist of five subunits: epsilon1, 2, 3, 4 and one zeta subunit. The zeta subunit is expressed throughout the brainstem whereas the four epsilon subunits display limited distribution. In mice, mutations in the gene encoding GluR- delta2 (GRID2) cause the Lurcher phenotype. The gene encoding human GluR- delta2 maps to chromosome 4q22.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: delta-2; GDH 2; GluD2; GluR delta-2 subunit; GluR delta2; GLURD2; Glutamate dehydrogenase 2, mitochondrial; glutamate dehydrogenase pseudogene 1; glutamate receptor delta-2 subunit; Glutamate receptor ionotropic; Glutamate receptor ionotropic, delta-2; glutamate receptor, ionotropic, delta 2; GRID2; testicular secretory protein Li 14
Gene Aliases: GDH2; GLUD2; GLUDP1; GLURD2; GRID2; SCAR18