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Invitrogen
GluR1 Polyclonal Antibody
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FIGURE: 1 / 2
GluR1 Antibody (PA5-95946) in IHC (P)
Immunohistochemistry analysis of GluR1 in paraffin-embedded mouse brain. Samples were incubated with GluR1 Polyclonal antibody (Product # PA5-95946) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
Product Details
PA5-95946
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 330-470 of human GluR1/GRIA1 (NP_0008182)
Conjugate
Form
Liquid
Concentration
0.66 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: PWGQGIDIQR ALQQVRFEGL TGNVQFNEKG RRTNYTLHVI EMKHDGIRKI GYWNEDDKFV PAATDAQAGG DNSSVQNRTY IVTTILEDPY VMLKKNANQF EGNDRYEGYC VELAAEIAKH VGYSYRLEIV SDGKYGARDP D
Positive Samples: BT-474; Cellular Location: Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum membrane, Multi-pass membrane protein, dendrite, dendritic spine, postsynaptic cell membrane, postsynaptic density, synapse
Target Information
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: AI853806; AMPA 1; AMPA-selective glutamate receptor 1; GluA1; GLUH 1; GluR K1; GluR-1; GluR-A; GluR-K1; GluR1; GluRK1; glutamate receptor; Glutamate receptor 1; glutamate receptor A; Glutamate receptor ionotropic, AMPA 1; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA1 (alpha 1); GPRC1A; Gria 1; GRM1A; HGBR1; HIPA; MGC13325; MGC133252; NMDA1; NMDAR1; NR1; OTTHUMP00000160643; OTTHUMP00000165781; OTTHUMP00000224241; OTTHUMP00000224242; OTTHUMP00000224243; RP11-350O14.1
Gene Aliases: 2900051M01Rik; Glr-1; Glr1; GLUA1; GLUH1; Glur-1; GluR-A; gluR-K1; GLUR1; GLURA; GRIA1; HBGR1; HIPA1
UniProt ID: (Human) P42261, (Rat) P19490, (Mouse) P23818
Entrez Gene ID: (Human) 2890, (Rat) 50592, (Mouse) 14799
AMPA glutamate receptor activity
excitatory extracellular ligand-gated ion channel activity
extracellular-glutamate-gated ion channel activity
protein binding
glutamate receptor activity
PDZ domain binding
G-protein alpha-subunit binding
ionotropic glutamate receptor activity
adenylate cyclase binding
protein kinase binding
protein domain specific binding
small GTPase binding
myosin V binding
G-protein beta-subunit binding
beta-2 adrenergic receptor binding
identical protein binding
protein homodimerization activity
protein kinase A binding
receptor activity
ion channel activity
transmembrane signal receptor
ER to Golgi vesicle-mediated transport
signal transduction
chemical synaptic transmission
long-term memory
receptor internalization
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
COPII vesicle coating
long term synaptic depression
regulation of receptor recycling
response to toxic substance
response to lithium ion
response to organic cyclic compound
neuronal action potential
spinal cord development
response to estradiol
synaptic transmission, glutamatergic
response to cocaine
response to drug
response to peptide hormone
positive regulation of membrane potential
response to arsenic-containing substance
regulation of synaptic plasticity
modulation of synaptic transmission
positive regulation of synaptic transmission
response to electrical stimulus
response to fungicide
cellular response to amino acid stimulus
cellular response to dsRNA
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
cellular response to organic cyclic compound
cellular response to amine stimulus
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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