Immunogen sequence: PWGQGIDIQR ALQQVRFEGL TGNVQFNEKG RRTNYTLHVI EMKHDGIRKI GYWNEDDKFV PAATDAQAGG DNSSVQNRTY IVTTILEDPY VMLKKNANQF EGNDRYEGYC VELAAEIAKH VGYSYRLEIV SDGKYGARDP D
Positive Samples: BT-474; Cellular Location: Cell junction, Cell membrane, Cell projection, Endoplasmic reticulum membrane, Multi-pass membrane protein, dendrite, dendritic spine, postsynaptic cell membrane, postsynaptic density, synapse
GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.
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Protein Aliases: AI853806; AMPA 1; AMPA-selective glutamate receptor 1; GluA1; GLUH 1; GluR K1; GluR-1; GluR-A; GluR-K1; GluR1; GluRK1; glutamate receptor; Glutamate receptor 1; glutamate receptor A; Glutamate receptor ionotropic, AMPA 1; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA1 (alpha 1); GPRC1A; Gria 1; GRM1A; HGBR1; HIPA; MGC13325; MGC133252; NMDA1; NMDAR1; OTTHUMP00000160643; OTTHUMP00000165781; OTTHUMP00000224241; OTTHUMP00000224242; OTTHUMP00000224243; RP11-350O14.1
Gene Aliases: 2900051M01Rik; Glr-1; Glr1; GluA1; GLUH1; Glur-1; GluR-A; gluR-K1; GLUR1; GLURA; GRIA1; HBGR1; HIPA1
Molecular Function: transmembrane signal receptor