This antibody is predicted to react with chicken, human, mouse and zebrafish based on 100% sequence homology.
This antibody is specific for the ~100 kDa GluR2/3 protein.
The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by alpha-amino-3-hydroxy-5 -methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994). The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD (Chung et al., 2003).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: AMPA 2; AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; GluA2; GluA3; GluR-2; GluR-3; GluR-B; GluR-C; GluR-K2; GluR-K3; GLUR2; Glutamate receptor 2; Glutamate receptor 3; glutamate receptor B; Glutamate receptor ionotropic; Glutamate receptor ionotropic, AMPA 2; Glutamate receptor ionotropic, AMPA 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA3 (alpha 3); GRIA2
Gene Aliases: GluA2; GluA3; GluR-3; gluR-B; GluR-C; GluR-K2; GluR-K3; GluR2; GLUR3; Gria2; Gria3