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Invitrogen
GluR2/GluR3 Polyclonal Antibody
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Product Details
PA1-4660
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Rat
Published species
Mouse,
Non-human primate
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the C-terminal region of rat GRIA2/3 conjugated to KLH
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Amount
25 µg
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with chicken, human, mouse and zebrafish based on 100% sequence homology.
This antibody is specific for the ~100 kDa GluR2/3 protein.
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA; R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AMPA-selective glutamate receptor 2; AMPA-selective glutamate receptor 3; GluR-2; GluR-3; GluR-B; GluR-C; GluR-K2; GluR-K3; glutamate receptor; Glutamate receptor 2; Glutamate receptor 3; glutamate receptor B; Glutamate receptor ionotropic, AMPA 2; Glutamate receptor ionotropic, AMPA 3; glutamate receptor, ionotrophic, AMPA 3; glutamate receptor, ionotropic, AMPA3 (alpha 3); GPRC1C; GRM3; MGR3
Gene Aliases: GluA2; GluA3; GluR-3; gluR-B; GluR-C; GluR-K2; GluR-K3; GluR2; GLUR3; Gria2; Gria3
UniProt ID: (Rat) P19491, (Rat) P19492
Entrez Gene ID: (Rat) 29627, (Rat) 29628
receptor activity
ionotropic glutamate receptor activity
AMPA glutamate receptor activity
extracellular-glutamate-gated ion channel activity
calcium channel regulator activity
protein binding
kainate selective glutamate receptor activity
protein kinase binding
PDZ domain binding
identical protein binding
transmembrane signal receptor
regulation of receptor recycling
chemical synaptic transmission
response to lithium ion
receptor internalization
ion transmembrane transport
ionotropic glutamate receptor signaling pathway
establishment of protein localization
positive regulation of synaptic transmission
protein tetramerization
regulation of synaptic transmission, glutamatergic
response to fungicide
synaptic transmission, glutamatergic
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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