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Glypican 2/GPC2 Polyclonal Antibody
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Product Details
BS-13450R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human Glypican 2/GPC2, amino acids 24-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Glypican 2 (GPC2) is a gene located on chromosome 7q22.1, encoding a member of the glypican family of heparan sulfate proteoglycans that are attached to the cell surface via a glycosylphosphatidylinositol (GPI) anchor. Glypicans are involved in the regulation of cell growth, differentiation, and morphogenesis, primarily through their interactions with growth factors and morphogens in the extracellular environment. GPC2 is prominently expressed in the nervous system and plays a significant role in neural development, influencing processes such as neuronal growth and axon guidance. Alterations in GPC2 expression have been linked to neurodevelopmental disorders and certain cancers, such as neuroblastoma, where it can act as an oncofetal antigen. GPC2 is being investigated for its potential as a therapeutic target and biomarker in oncology due to its involvement in tumorigenesis and cancer progression. Research continues to explore its functional mechanisms and its implications in both neurobiology and cancer therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Cerebroglycan; cerebroglycan proteoglycan; glypican proteoglycan 2, cerebroglycan proteoglycan; Glypican-2; HSPG M13; unnamed protein product
Gene Aliases: 2410016G05Rik; GPC2
UniProt ID: (Human) Q8N158, (Rat) P51653, (Mouse) Q8BKV1
Entrez Gene ID: (Human) 221914, (Rat) 171517, (Mouse) 71951
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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