This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated. View Details
For IHC (paraffin) procedures perform heat mediated antigen retrieval using 10mM citrate buffer (p.H. 6.0) before commencing with the IHC staining protocol.
Positive Control: Tonsil
Granzyme B is a member of the granzyme serine protease family, and is found in the granules of cytotoxic T cells and NK cells. Granzyme B has been described as CGL1 (cathepsin G-like-1), a serine protease expressed only in cytotoxic T-lymphocytes after cell activation, and CTLA-1 (cytotoxic T lymphocyte-associated serine esterase 1) based on identification of mRNA in various cytotoxic T cells, but not observed in non-cytotoxic lymphoid cells. Granzyme B is crucial for the rapid induction of target cell death by apoptosis, induced by interaction with cytotoxic T cells. The receptor involved in this process has been identified as mannose 6-phosphate receptor which functions as a death receptor for Granzyme B during cytotoxic T cell-induced apoptosis. Granzyme B enters target cells to cleave caspase-3 and initiate the caspase cascade leading to DNA fragmentation and apoptosis. Granzyme B can also act through a mitochondrial apoptosis pathway by cleaving the Bid protein. Granzymes are neutral serine proteases, which are stored in specialized lytic granules of cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells. A number of granzymes (A to G) have been isolated and cloned from mouse CTLs and NK cells, however in man, fewer have been cloned and identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C11; Cathepsin G-like 1; CCP1; CTLA-1; CTSGL1; Cytotoxic cell protease 1; cytotoxic serine protease B; Cytotoxic T-lymphocyte proteinase 2; cytotoxic T-lymphocyte-associated serine esterase 1; Fragmentin; fragmentin 2; Fragmentin-2; GLP I; GLP III; GLP-1; granzyme 2; Granzyme B; granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1); Granzyme B(G,H); Granzyme-2; granzyme-like protein 1; granzyme-like protein I; GranzymeB; HLP; Human lymphocyte protein; Lymphocyte protease; Natural killer cell protease 1; OTTHUMP00000028189; RNKP-1; SECT; T-cell serine protease 1-3E
Gene Aliases: AI553453; CCP-1/C11; CCP1; CCPI; CGL-1; CGL1; CSP-B; CSPB; Ctla-1; CTLA1; CTSGL1; GRB; GZB; GZMB; HLP; RNKP-1; SECT