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Invitrogen

Growth Hormone Receptor Polyclonal Antibody

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Growth Hormone Receptor Polyclonal Antibody

Product Details

PA5-79309

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-0.5 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to a sequence in the middle region of mouse Growth hormone receptor (231-247aa DKEHEVRVRSRQRSFEK).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

500 µg/mL

Amount

100 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS with 5mg BSA

Contains

0.05mg sodium azide, 0.05mg thimerosal

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2746425

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Positive Control - WB: Rat Liver Tissue, Rat Kidney Tissue, Rat Spleen Tissue, Rat Intestine Tissue, Mouse Spleen Tissue, Mouse Testis Tissue, Mouse Liver Tissue, Mouse Kidney Tissue, Mouse Intestine Tissue.

Target Information

Growth hormone receptor (GHR) is a gene located on chromosome 5p13.1, encoding a transmembrane receptor that plays a critical role in mediating the effects of growth hormone, which is crucial for growth, metabolism, and tissue development. GHR is expressed in various tissues, including the liver, muscle, and adipose tissue, and facilitates the growth hormone signaling pathway by binding to growth hormone, leading to receptor dimerization and activation of intracellular signaling cascades such as the JAK2-STAT5 pathway. This signaling promotes growth and anabolic processes, influencing body composition, insulin sensitivity, and lipid metabolism. Mutations or alterations in the GHR gene can lead to growth disorders like Laron syndrome, characterized by insensitivity to growth hormone. Understanding GHR's structure and function is pivotal for developing therapeutic strategies for growth deficiencies and metabolic syndromes, as modifying GHR signaling pathways can offer potential interventions in related conditions.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: GH receptor; Growth hormone receptor; Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein); growth hormone receptor precursor splice variant D56; growth hormone receptor variant d5-6; growth hormone receptor/binding protein; MGC124963; MGC156665; Somatotropin receptor

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Gene Aliases: GHBP; Ghr; GHR/BP

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UniProt ID: (Rat) P16310, (Mouse) P16882

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Entrez Gene ID: (Rat) 25235, (Mouse) 14600

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Function(s)
growth hormone receptor activity peptide hormone binding growth factor binding protein kinase binding protein phosphatase binding SH2 domain binding protein homodimerization activity cytokine receptor activity protein binding transmembrane signal receptor
Process(es)
activation of MAPK activity allantoin metabolic process citrate metabolic process 2-oxoglutarate metabolic process succinate metabolic process oxaloacetate metabolic process isoleucine metabolic process valine metabolic process creatine metabolic process fatty acid metabolic process JAK-STAT cascade response to hormone hormone-mediated signaling pathway cytokine-mediated signaling pathway taurine metabolic process receptor internalization response to food response to estradiol cellular response to insulin stimulus cellular response to hormone stimulus response to cytokine regulation of multicellular organism growth positive regulation of multicellular organism growth activation of Janus kinase activity activation of JAK2 kinase activity response to morphine response to peptide hormone multicellular organism metabolic process positive regulation of cell differentiation positive regulation of JAK-STAT cascade creatinine metabolic process response to cycloheximide insulin-like growth factor receptor signaling pathway positive regulation of peptidyl-tyrosine phosphorylation response to glucocorticoid cartilage development involved in endochondral bone morphogenesis growth hormone receptor signaling pathway response to interleukin-1 negative regulation of neuron death endocytosis
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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