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Agrisera
Grx5/Monothiol glutaredoxin-S5 Polyclonal Antibody
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Product Details
AS15-3108
Product Specifications
Species Reactivity
Plant
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
His-tagged, full length recombinant Grx5 of Arabidopsis thaliana.
Conjugate
Form
Lyophilized
Storage buffer
whole serum
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.
For reconstitution add 50 µL of sterile water.
Specific Species Reactivity: Arabidopsis thaliana
Target Information
GLRX5 encodes a conserved mitochondrial glutaredoxin that is synthesized as a precursor bearing an N-terminal mitochondrial targeting sequence and is imported to the mitochondrial matrix, where it functions in iron-sulfur (Fe-S) cluster biogenesis and cellular iron homeostasis. The protein is a small monothiol glutaredoxin family member with a single glutaredoxin-like domain and a characteristic CGFS active-site motif that supports coordination/handling of a [2Fe-2S] cluster, consistent with a role as an Fe-S cluster transfer/assembly factor within the mitochondrial ISC machinery. Functionally, GLRX5 is required for maturation of mitochondrial Fe-S proteins and for maintaining proper distribution of iron between mitochondrial and cytosolic pools; loss of GLRX5 activity impairs Fe-S cluster formation, perturbs iron regulation, and in erythroid cells can secondarily compromise heme biosynthesis by disrupting Fe-S-dependent steps and iron-responsive regulatory pathways, causing autosomal recessive pyridoxine-refractory sideroblastic anemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C14orf87; FLB4739; GRX5; PR01238; PRO1238; PRSA; SIDBA3; SPAHGC
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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