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Proteintech
H2AFY2 Polyclonal Antibody
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Product Details
17030-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
H2AFY2 Fusion Protein Ag10487 (1-372 aa encoded by BC016172)
Conjugate
Form
Liquid
Concentration
0.32 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSGRSGKKK MSKLSRSARA GVIFPVGRLM RYLKKGTFKY RISVGAPVYM AAVIEYLAAE ILELAGNAAR DNKKARIAPR HILLAVANDE ELNQLLKGVT IASGGVLPRI HPELLAKKRG TKGKSETILS PPPEKRGRKA TSGKKGGKKS KAAKPRTSKK SKPKDSDKEG TSNSTSEDGP GDGFTILSSK SLVLGQKLSL TQSDISHIGS MRVEGIVHPT TAEIDLKEDI GKALEKAGGK EFLETVKELR KSQGPLEVAE AAVSQSSGLA AKFVIHCHIP QWGSDKCEEQ LEETIKNCLS AAEDKKLKSV AFPPFPSGRN CFPKQTAAQV TLKAISAHFD DSSASSLKNV YFLLFDSESI GIYVQEMAKL DAK (1-372 aa encoded by BC016172)
Target Information
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Core histone macro-H2A.2; core histone macroH2A2.2; H2A histone family, member Y2; Histone macroH2A2; histone mH2A2; mH2A2
Gene Aliases: H2AFY2; H2afy3; MACROH2A2; RGD1561371
UniProt ID: (Human) Q9P0M6, (Mouse) Q8CCK0
Entrez Gene ID: (Human) 55506, (Rat) 361844, (Mouse) 404634
negative regulation of transcription from RNA polymerase II promoter
regulation of cell growth
nucleosome assembly
chromatin silencing
brain development
dosage compensation
covalent chromatin modification
positive regulation of keratinocyte differentiation
negative regulation of gene expression, epigenetic
establishment of protein localization to chromatin
negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
biological_process
chromatin modification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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