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Invitrogen
HAND2 Polyclonal Antibody
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Product Details
PA5-64981
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human HAND2. Recombinant protein control fragment (Product #RP-104565).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SLVGGFPHHPV VHHEGYPFAA AAAAAAAAAA SRCSHEENPY FHGWLIGHPE MSPPDYSMAL SY
Highest antigen sequence identity to the following orthologs - mouse 100%, rat 70%.
Target Information
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: basic helix-loop-helix transcription factor HAND2; bHLHa26; Class A basic helix-loop-helix protein 26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND; Heart- and neural crest derivatives-expressed protein 2; unnamed protein product
Gene Aliases: BHLHA26; DHAND; DHAND2; HAND2; Hed; Thing2
UniProt ID: (Human) P61296
Entrez Gene ID: (Human) 9464
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription coactivator binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
AT DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
sequence-specific DNA binding
protein dimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
E-box binding
sequence-specific double-stranded DNA binding
angiogenesis
osteoblast differentiation
in utero embryonic development
heart looping
suckling behavior
heart morphogenesis
outflow tract morphogenesis
cardiac right ventricle formation
cardiac neural crest cell migration involved in outflow tract morphogenesis
regulation of secondary heart field cardioblast proliferation
apoptotic process involved in heart morphogenesis
noradrenergic neuron differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
apoptotic process
heart development
adult heart development
mesenchymal cell proliferation
positive regulation of cardiac muscle hypertrophy
positive regulation of gene expression
negative regulation of gene expression
negative regulation of cardiac muscle cell apoptotic process
neural crest cell development
cell differentiation
regulation of tissue remodeling
norepinephrine biosynthetic process
odontogenesis of dentin-containing tooth
embryonic digit morphogenesis
tongue development
negative regulation of osteoblast differentiation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
sympathetic nervous system development
thymus development
embryonic skeletal system development
peripheral nervous system neuron development
palate development
mesenchyme development
cartilage morphogenesis
coronary artery morphogenesis
visceral serous pericardium development
cardiac neural crest cell development involved in outflow tract morphogenesis
cell proliferation involved in outflow tract morphogenesis
determination of heart left/right asymmetry
positive regulation of ERK1 and ERK2 cascade
cellular response to retinoic acid
positive regulation of p38MAPK cascade
primary palate development
epithelial cell apoptotic process
negative regulation of epithelial cell apoptotic process
positive regulation of semaphorin-plexin signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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