Immunogen sequence: MSLVGGFPHH PVVHHEGYPF AAAAAAAAAA AASRCSHEEN PYFHGWLIGH PEMSPPDYSM ALSYSPEYAS GAAGLDHSHY GGVPPGAGPP GLGGPRPVKR RGTANRKERR RTQSINSAFA ELRECIPNVP ADTKLSKIKT LRLATSYIAY LMDLLAKDDQ NGEAEAFKAE IKKTDVKEEK RKKELNEILK STVSSNDKKT KGRTGWPQHV WALELKQ; Positive Samples: Mouse liver, Mouse heart; Cellular Location: Nucleus
The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development.
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Protein Aliases: basic helix-loop-helix transcription factor HAND2; bHLHa26; Class A basic helix-loop-helix protein 26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; dHAND; dHand protein; heart and neural crest derivatives expressed transcript 2; Heart- and neural crest derivatives-expressed protein 2; Helix-loop-helix transcription factor expressed in embryo and deciduum; Thing-2
Gene Aliases: AI225906; AI661148; BHLHA26; DHAND; DHAND2; Ehand2; HAND2; Hed; Th2; Thing2