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Proteintech
HDAC2 Polyclonal Antibody
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Product Details
16152-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human HDAC2 and is specific to HDAC2. It will not cross react with other HDACs.
Target Information
HDAC2 belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HD2; hdac 2; hdac-2; Histone deacetylase 2; Protein deacylase HDAC2; transcriptional regulator homolog RPD3; unnamed protein product; YY1-associated factor 1
Gene Aliases: HD2; HDAC2; KDAC2; RPD3; YAF1
UniProt ID: (Human) Q92769
Entrez Gene ID: (Human) 3066
transcription cofactor binding
chromatin binding
RNA binding
histone deacetylase activity
protein binding
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
deacetylase activity
enzyme binding
heat shock protein binding
nucleosomal DNA binding
protein deacetylase activity
histone binding
histone deacetylase binding
NF-kappaB binding
RNA polymerase II sequence-specific DNA binding transcription factor binding
DNA-binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
protein decrotonylase activity
histone decrotonylase activity
protein de-2-hydroxyisobutyrylase activity
protein lysine delactylase activity
promoter-specific chromatin binding
negative regulation of transcription from RNA polymerase II promoter
response to amphetamine
cardiac muscle hypertrophy
chromatin organization
chromatin remodeling
positive regulation of cell proliferation
response to xenobiotic stimulus
epidermal cell differentiation
positive regulation of epithelial to mesenchymal transition
negative regulation of transcription by competitive promoter binding
negative regulation of neuron projection development
dendrite development
negative regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
response to caffeine
heterochromatin assembly
response to lipopolysaccharide
positive regulation of interleukin-1 production
positive regulation of tumor necrosis factor production
circadian regulation of gene expression
positive regulation of intracellular estrogen receptor signaling pathway
cellular response to heat
response to nicotine
protein modification process
response to cocaine
odontogenesis of dentin-containing tooth
regulation of cell fate specification
embryonic digit morphogenesis
negative regulation of apoptotic process
positive regulation of proteolysis
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
behavioral response to ethanol
rhythmic process
positive regulation of oligodendrocyte differentiation
progesterone receptor signaling pathway
response to hyperoxia
hair follicle placode formation
negative regulation of dendritic spine development
eyelid development in camera-type eye
fungiform papilla formation
cellular response to hydrogen peroxide
cellular response to retinoic acid
cellular response to transforming growth factor beta stimulus
response to alcohol
positive regulation of male mating behavior
negative regulation of stem cell population maintenance
positive regulation of stem cell population maintenance
cellular response to dopamine
response to amyloid-beta
regulation of stem cell differentiation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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