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Active Motif
HDAC3 Polyclonal Antibody
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Product Details
40968
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
This HDAC3 antibody was raised against a synthetic peptide corresponding to amino acid residues 2-17 of human HDAC3.
Conjugate
Form
Liquid
Concentration
1.0 mg/mL
Purification
Protein G
Storage buffer
PBS, pH 7.5
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. HDAC3 belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HD3; Histone deacetylase 3; Protein deacetylase HDAC3; Protein deacylase HDAC3; RPD3-2; SMAP45
Gene Aliases: HD3; HDAC3; RPD3; RPD3-2
UniProt ID: (Human) D3DQE1
Entrez Gene ID: (Human) 8841
negative regulation of transcription from RNA polymerase II promoter
positive regulation of protein phosphorylation
transcription, DNA-templated
protein deacetylation
circadian rhythm
negative regulation of myotube differentiation
chromatin modification
regulation of protein stability
positive regulation of TOR signaling
positive regulation of transcription factor import into nucleus
negative regulation of apoptotic process
cellular lipid metabolic process
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
spindle assembly
histone H3 deacetylation
cellular response to fluid shear stress
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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