This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. View Details
MA5-15580 targets HDAC4 in WB applications and shows reactivity with Human samples.
The MA5-15580 immunogen is purified recombinant fragment of human HDAC4 expressed in E. Coli.
MA5-15580 detects HDAC4 which has a predicted molecular weight of approximately 119kDa.
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HA6116; HD4; HDAC-A; HDAC4; HDACA; Histone deacetylase 4; histone deacetylase A; KIAA0288
Gene Aliases: 4932408F19Rik; AHO3; AI047285; BDMR; HA6116; HD4; HDAC-4; HDAC-A; HDAC4; HDACA; KIAA0288