Suggested positive control: antigen standard for HDAC6 (transient overexpression lysate), NIH-3T3 whole cell lysate.
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ16239; HD6; HDA6; histone deacetylase 5; Histone deacetylase 6; Histone deacetylase mHDA2; protein phosphatase 1, regulatory subunit 90; scurfy candidate 6; Tubulin-lysine deacetylase HDAC6
Gene Aliases: CPBHM; HD6; Hdac5; HDAC6; JM21; KIAA0901; mHDA2; PPP1R90; Sfc6
Molecular Function: chromatin/chromatin-binding, or -regulatory protein histone modifying enzyme