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Proteintech
HDAC8 Polyclonal Antibody
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Product Details
17548-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HDAC8 Fusion Protein Ag11696 (1-377 aa encoded by BC050433)
Conjugate
Form
Liquid
Concentration
0.14 mg/mL
Amount
21 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is a rabbit polyclonal antibody raised against full length HDAC8 of human origin.
Immunogen sequence: MEEPEEPAD SGQSLVPVYI YSPEYVSMCD SPAKIPKRAS MVHSLIEAYA LHKQMRIVKP KVASMEEMAT FHTDAYLQHL QKVSQEGDDD HPDSIEYGLG YDCPATEGIF DYAAAIGGAT ITAAQCLIDG MCKVAINWSG GWHHAKKDEA SGFCYLNDAV LGILRLRRKF ERILYVDLDL HHGDGVEDAF SFTSKVMTVS LHKFSPGFFP GTGDVSDVGL GKGRYYSVNV PIQDGIQDEK YYQICESVLK EVYQAFNPKA VVLQLGADTI AGDPMCSFNM TPVGIGKCLK YILQWQLATL ILGGGGYNLA NTARCWTYLT GVILGKTLSS EIPDHEFFTA YGPDYVLEIT PSCRPDRNEP HRIQQILNYI KGNLKHVV (1-377 aa encoded by BC050433)
Target Information
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HD8; Histone deacetylase 8; histone deacetylase-like 1; Protein deacetylase HDAC8; Protein decrotonylase HDAC8; unnamed protein product
Gene Aliases: 2610007D20Rik; CDA07; CDLS5; HD8; HDAC8; HDACL1; KDAC8; MRXS6; RGD1562895; RPD3; WTS
UniProt ID: (Human) Q9BY41, (Rat) B1WC68, (Mouse) Q8VH37
Entrez Gene ID: (Human) 55869, (Rat) 363481, (Mouse) 70315
histone deacetylase activity
protein binding
hydrolase activity
Hsp70 protein binding
protein deacetylase activity
metal ion binding
Hsp90 protein binding
DNA-binding transcription factor binding
histone deacetylase activity, hydrolytic mechanism
protein decrotonylase activity
histone decrotonylase activity
NAD-dependent histone deacetylase activity (H3-K14 specific)
NAD-dependent histone deacetylase activity (H3-K9 specific)
NAD-dependent histone deacetylase activity (H4-K16 specific)
NAD-dependent histone deacetylase activity (H3-K18 specific)
transcription factor binding
histone deacetylase activity (H3-K14 specific)
histone deacetylase activity (H3-K9 specific)
histone deacetylase activity (H4-K16 specific)
transcription, DNA-templated
regulation of transcription, DNA-templated
sister chromatid cohesion
histone H3-K9 modification
histone H3 deacetylation
histone H4 deacetylation
regulation of cohesin loading
negative regulation of transcription from RNA polymerase II promoter
chromatin organization
mitotic sister chromatid cohesion
negative regulation of protein ubiquitination
heterochromatin assembly
regulation of protein stability
regulation of telomere maintenance
chromatin modification
histone deacetylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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