HEMGN regulates the proliferation and differentiation of hematopoietic cells. Overexpression of HEMGN block the TPA-induced megakaryocytic differentiation in the K562 cell model. HEMGN may also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB).
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Protein Aliases: EDAG-1; Erythroid differentiation-associated gene protein; Hemogen; Hemopoietic gene protein; mNDR; Negative differentiation regulator protein; nuclear protein
Gene Aliases: 4921524M03Rik; AI317176; CT155; EDAG; EDAG-1; HEMGN; Hgn; mNDR; NDR; PRO1037; PRO1620