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Proteintech
HERC5 Polyclonal Antibody
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Product Details
22692-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HERC5 Fusion Protein Ag18449 (1-342 aa encoded by BC140716)
Conjugate
Form
Liquid
Concentration
0.21 mg/mL
Amount
31.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MERRSRRKS RRNGRSTAGK AAATQPAKSP GAQLWLFPSA AGLHRALLRR VEVTRQLCCS PGRLAVLERG GAGVQVHQLL AGSGGARTPK CIKLGKNMKI HSVDQGAEHM LILSSDGKPF EYDNYSMKHL RFESILQEKK IIQITCGDYH SLALSKGGEL FAWGQNLHGQ LGVGRKFPST TTPQIVEHLA GVPLAQISAG EAHSMALSMS GNIYSWGKNE CGQLGLGHTE SKDDPSLIEG LDNQKVEFVA CGGSHSALLT QDGLLFTFGA GKHGQLGHNS TQNELRPCLV AELVGYRVTQ IACGRWHTLA YVSDLGKVFS FGSGKDGQLG NGGTRDQLMP LPV (1-342 aa encoded by BC140716)
Target Information
HERC5 (E3 ISG15 - protein ligase HERC5) is a major E3 ligase for ISG15 conjugation. It acts a positive regulator of innate antiviral response in cells induced by interferon. HERC5 functions as a part of the ISGylation machinery that recognizes target protein in a broad and relatively non-specific manner. It catalyzes ISGylation of IRF3 - which results in sustained activation, it attenuates IRF3-PIN1 interaction - which antagonizes IFR3 ubiquitination and degradation, and boosts the antiviral repsonse. HERC5 is physically assocated with polyribosomes and broadly modifies newly synthesized proteins in a cotranslational manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Cyclin-E-binding protein 1; E3 ISG15--protein ligase HERC5; HECT domain and RCC1-like domain-containing protein 5; hect domain and RLD 5; probable E3 ubiquitin-protein ligase HERC5; ubiquitin ligase; unnamed protein product
Gene Aliases: CEB1; CEBP1; HERC5
UniProt ID: (Human) Q9UII4
Entrez Gene ID: (Human) 51191
regulation of cyclin-dependent protein serine/threonine kinase activity
immune system process
ubiquitin-dependent protein catabolic process
protein ubiquitination
ISG15-protein conjugation
PKR/eIFalpha signaling
innate immune response
regulation of defense response to virus
defense response to virus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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