Proteintech

HES5 Polyclonal Antibody

12 References
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Datasheet
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Datasheet
Protocols
Questions & Answers
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Datasheet
Protocols
Questions & Answers
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Product Details

22666-1-AP

Applications
Tested Dilution
Publications

Western Blot (WB)

1:200-1:1,000
View 11 publications 11 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200
-

Not applicable (N/A)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HES5 Fusion Protein Ag18270 (1-172 aa encoded by BC087840)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.25 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MRRDRINSS IEQLKLLLEQ EFARHQPNSK LEKADILEMA VSYLKHSKGE RARAPRAPSS HRAPAPPRPA ARSPPPRLPA AFVAAAGPKS LHQDYSEGYS WCLQEAVQFL TLHAASDTQM KLLYHFQRPP AAPAAPAKEP KAPGAAPPPA LSAKATAAAA AAHQPACGLW RPW (1-172 aa encoded by BC087840)

Target Information

Hairy and Enhancer-of-split homologues 5 (HES5) is a helix-loop-helix transcriptional factor that negatively regulates cell differentiation during embryogenesis. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. HES5 is reported to be a down stream effector of the Notch Signaling Pathway and is expressed in advanced ovarian serous adenocarcinomas as well as in cervical squamous carcinoma. Reports also suggest that HES5 is abundantly expressed in osteoarthritis along with Notch1 and Jagged1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: bHLHb38; Class B basic helix-loop-helix protein 38; Hairy and enhancer of split 5; RP3-395M20.5; Transcription factor HES-5

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Gene Aliases: BHLHB38; Hes-5; HES5

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UniProt ID: (Human) Q5TA89, (Rat) Q03062, (Mouse) P70120

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Entrez Gene ID: (Human) 388585, (Rat) 79225, (Mouse) 15208

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Function(s)
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding chromatin binding double-stranded DNA binding transcription factor binding protein dimerization activity DNA binding protein binding basic helix-loop-helix transcription factor
Process(es)
negative regulation of transcription from RNA polymerase II promoter chondrocyte differentiation transcription, DNA-templated protein complex assembly cell adhesion Notch signaling pathway smoothened signaling pathway brain development positive regulation of cell proliferation oligodendrocyte development telencephalon development glial cell fate commitment forebrain radial glial cell differentiation neural tube development central nervous system myelination positive regulation of BMP signaling pathway regulation of myelination auditory receptor cell differentiation positive regulation of tyrosine phosphorylation of Stat3 protein auditory receptor cell fate determination camera-type eye development regulation of cell differentiation regulation of auditory receptor cell differentiation negative regulation of neuron differentiation positive regulation of Notch signaling pathway positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of JAK-STAT cascade cell maturation positive regulation of smooth muscle cell proliferation astrocyte differentiation negative regulation of astrocyte differentiation negative regulation of oligodendrocyte differentiation regulation of epithelial cell proliferation regulation of neurogenesis cartilage development inner ear receptor stereocilium organization comma-shaped body morphogenesis S-shaped body morphogenesis specification of loop of Henle identity metanephric nephron tubule morphogenesis establishment of epithelial cell polarity neuronal stem cell population maintenance negative regulation of stem cell differentiation negative regulation of pro-B cell differentiation negative regulation of forebrain neuron differentiation negative regulation of inner ear receptor cell differentiation transcription from RNA polymerase II promoter neuron differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated multicellular organism development nervous system development cell differentiation
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