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Proteintech
HES5 Polyclonal Antibody
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Product Details
22666-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HES5 Fusion Protein Ag18270 (1-172 aa encoded by BC087840)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MRRDRINSS IEQLKLLLEQ EFARHQPNSK LEKADILEMA VSYLKHSKGE RARAPRAPSS HRAPAPPRPA ARSPPPRLPA AFVAAAGPKS LHQDYSEGYS WCLQEAVQFL TLHAASDTQM KLLYHFQRPP AAPAAPAKEP KAPGAAPPPA LSAKATAAAA AAHQPACGLW RPW (1-172 aa encoded by BC087840)
Target Information
Hairy and Enhancer-of-split homologues 5 (HES5) is a helix-loop-helix transcriptional factor that negatively regulates cell differentiation during embryogenesis. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. HES5 is reported to be a down stream effector of the Notch Signaling Pathway and is expressed in advanced ovarian serous adenocarcinomas as well as in cervical squamous carcinoma. Reports also suggest that HES5 is abundantly expressed in osteoarthritis along with Notch1 and Jagged1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: bHLHb38; Class B basic helix-loop-helix protein 38; Hairy and enhancer of split 5; Notch pathway transcription factor; RP3-395M20.5; Transcription factor HES-5
Gene Aliases: BHLHB38; Hes-5; HES5
UniProt ID: (Human) Q5TA89, (Rat) Q03062, (Mouse) P70120
Entrez Gene ID: (Human) 388585, (Rat) 79225, (Mouse) 15208
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
protein dimerization activity
sequence-specific double-stranded DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
chromatin binding
double-stranded DNA binding
protein binding
transcription factor binding
basic helix-loop-helix transcription factor
negative regulation of transcription from RNA polymerase II promoter
chondrocyte differentiation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
cell adhesion
Notch signaling pathway
smoothened signaling pathway
nervous system development
brain development
positive regulation of cell proliferation
anterior/posterior pattern specification
oligodendrocyte development
telencephalon development
glial cell fate commitment
neural tube development
central nervous system neuron differentiation
central nervous system myelination
cell differentiation
neuron differentiation
BMP signaling pathway
positive regulation of BMP signaling pathway
regulation of myelination
auditory receptor cell differentiation
camera-type eye development
regulation of cell differentiation
negative regulation of cell differentiation
negative regulation of auditory receptor cell differentiation
regulation of neuron differentiation
negative regulation of neuron differentiation
positive regulation of Notch signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JAK-STAT cascade
cell maturation
animal organ development
positive regulation of smooth muscle cell proliferation
astrocyte differentiation
oligodendrocyte differentiation
negative regulation of astrocyte differentiation
negative regulation of oligodendrocyte differentiation
system development
regulation of epithelial cell proliferation
regulation of neurogenesis
cartilage development
inner ear receptor stereocilium organization
protein-containing complex assembly
comma-shaped body morphogenesis
S-shaped body morphogenesis
specification of loop of Henle identity
metanephric nephron tubule morphogenesis
establishment of epithelial cell polarity
neuronal stem cell population maintenance
negative regulation of stem cell differentiation
negative regulation of pro-B cell differentiation
negative regulation of inner ear receptor cell differentiation
transcription, DNA-templated
transcription from RNA polymerase II promoter
protein complex assembly
forebrain radial glial cell differentiation
positive regulation of tyrosine phosphorylation of Stat3 protein
auditory receptor cell fate determination
negative regulation of forebrain neuron differentiation
multicellular organism development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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