This target displays homology in the following species: Cow: 79%; Dog: 79%; Guinea Pig: 100%; Horse: 93%; Human: 100%; Mouse: 93%; Rat: 100%
Hairy/enhancer-of-split related with YRPW motif protein 1 belongs to the HEY family and is a Notch Signaling Pathway Protein. It contains one basic helix-loop-helix (bHLH) domain and one Orange domain. It is a downstream effector of Notch signaling which may be required for cardiovascular development. It acts as transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. It represses transcription by the cardiac transcriptional activators GATA4 and GATA6. Hey1 is also reported to be expressed during development of the nervous system.
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Protein Aliases: basic helix-loop-helix protein OAF1; bHLH protein Hesr-1/Hey1; BHLHb31; cardiovascular basic helix-loop-helix factor 2; Cardiovascular helix-loop-helix factor 2; CHF-2; CHF2; Class B basic helix-loop-helix protein 31; Hairy and enhancer of split-related protein 1; Hairy-related transcription factor 1; Hairy/E(spl)-related with YRPW motif 1; hairy/enhancer-of-split related with YRPW motif 1; Hairy/enhancer-of-split related with YRPW motif protein 1; HERP2; hes-related family bHLH transcription factor with YRPW motif 1; HES-related repressor protein 1; HES-related repressor protein 2; HESR-1; HESR1; hHRT1; HRT-1; mHRT1; OAF1
Gene Aliases: AI316788; AI414254; BC8; BHLHB31; BOS_13914; CHF2; HERP2; hesr-1; HESR1; HEY1; hHRT1; HRT-1; HRT1; OAF1