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HIPPI Polyclonal Antibody
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FIGURE: 1 / 2
HIPPI Antibody (BS-11697R) in WB
Lane 1: Mouse Lymph node lysates; Lane 2: Mouse Lung lysates probed with HIPPI Polyclonal Antibody, Unconjugated (bs-11697R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37°C.
Product Details
BS-11697R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human HIPPI, amino acids 331-429.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
HIPPI is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: death effector domain-containing protein; Dermal papilla-derived protein 8; ESRRBL1; estrogen-related receptor beta like 1; Estrogen-related receptor beta-like protein 1; FLJ10147; HIP1 protein interactor; HIP1-interacting protein; huntingtin interacting protein-1 interacting protein; huntingtin-interacting protein-1 protein interactor; intraflagellar transport 57 homolog; Intraflagellar transport protein 57 homolog; MHS4R2; nuclear; unnamed protein product; Vestrogen-related receptor beta like 1
Gene Aliases: 4833420A15Rik; DERP8; ESRRBL1; HIPPI; IFT57; MHS4R2; OFD18
UniProt ID: (Human) Q9NWB7, (Mouse) Q8BXG3
Entrez Gene ID: (Human) 55081, (Mouse) 73916, (Rat) 303968
neural tube closure
heart looping
apoptotic process
smoothened signaling pathway
negative regulation of keratinocyte proliferation
intraciliary anterograde transport
intraciliary transport
regulation of apoptotic process
keratinocyte proliferation
motile cilium assembly
cilium morphogenesis
left/right pattern formation
non-motile cilium assembly
transcription, DNA-templated
regulation of transcription, DNA-templated
activation of cysteine-type endopeptidase activity involved in apoptotic process
cilium assembly
negative regulation of epithelial cell proliferation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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