HIPPI is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
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Protein Aliases: Dermal papilla-derived protein 8; estrogen-related receptor beta like 1; Estrogen-related receptor beta-like protein 1; FLJ10147; HIP1 protein interactor; HIP1-interacting protein; huntingtin interacting protein-1 interacting protein; intraflagellar transport 57 homolog; Intraflagellar transport protein 57 homolog; MHS4R2
Gene Aliases: DERP8; ESRRBL1; HIPPI; IFT57; MHS4R2
UniProt ID: (Human) Q9NWB7
Entrez Gene ID: (Human) 55081
Molecular Function: structural protein