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Product Details
MA5-25044
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI4F6
Immunogen
Full length human recombinant protein of IFT57 produced in HEK293T cell
Conjugate
Unconjugated
Form
Liquid
Concentration
1.0 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2724451
Target Information
HIPPI is required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dermal papilla-derived protein 8; estrogen-related receptor beta like 1; Estrogen-related receptor beta-like protein 1; FLJ10147; HIP1 protein interactor; HIP1-interacting protein; huntingtin interacting protein-1 interacting protein; intraflagellar transport 57 homolog; Intraflagellar transport protein 57 homolog; MHS4R2
Gene Aliases: DERP8; ESRRBL1; HIPPI; IFT57; MHS4R2
UniProt ID: (Human) Q9NWB7
Entrez Gene ID: (Human) 55081
Molecular Function:
structural protein
neural tube closure
heart looping
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
activation of cysteine-type endopeptidase activity involved in apoptotic process
smoothened signaling pathway
intraciliary transport
cilium assembly
regulation of apoptotic process
negative regulation of epithelial cell proliferation
left/right pattern formation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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