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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.
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Protein Aliases: H2A histone family member; H2A-clustered histone 12; histone 1, H2ah; Histone H2A type 1-H; Histone H2A/s; similar to Histone H2A type 1
Gene Aliases: dJ86C11.1; H2A/S; H2AC12; H2AFALii; H2AH; HIST1H2AH; HIST1H2AI
UniProt ID: (Human) Q96KK5, (Mouse) Q8CGP6
Entrez Gene ID: (Human) 85235, (Mouse) 319168, (Rat) 680322
Molecular Function: histone
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