Immunogen sequence: KKIDKYLYAM RLSDETLIDI MTRFRKEMKN GLSRDFNPTA TVKMLPTFVR SIPDGSEKGD FIALDLGGSS FRILRVQVNH EKNQNVHMES EVYDTPENIV HGSGSQLFDH VAECLGDFME KRKIKDKKLP VGFTFSFPCQ QSKIDEAILI TWTKRFKASG VEGADVVKLL NKAIKKRGDY DANIVAVVND TVGTMMTCGY DDQHCEVGLI IGTGTNACYM EELRHIDLVE GDEGRMCINT EWGAFGDDGS LEDIRTEFDR EIDRGSLNPG KQLFEKMVSG M; Positive Samples: MCF7, 293T, Jurkat, THP-1, NIH/3T3, K-562, Mouse skeletal muscle, rat testis; Cellular Location: Mitochondrion outer membrane
This gene encodes a member of the ARHGAP family of Rho/Rac/Cdc42-like GTPase activating proteins. The encoded protein interacts with the Ras-related protein Gem through its N-terminal domain. Separately, it interacts with RhoA through a RhoGAP domain, and stimulates RhoA-dependent GTPase activity. Alternatively spliced variants that encode different protein isoforms have been described but their full-length nature has not been determined.
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Protein Aliases: Brain form hexokinase; downeast anemia; glycolytic enzyme; hexokinase I; hexokinase IR; Hexokinase type I; Hexokinase, tumor isozyme; Hexokinase-1; Hexokinase-A; HK I
Gene Aliases: BB404130; dea; HEXOKIN; hexokinase; HK; Hk-1; HK1; Hk1-s; HK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1; mHk1-s