|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 11 and 260 of Human HLA-DPA1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28037 targets HLA-DPA1 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-28037 immunogen is recombinant fragment corresponding to a region within amino acids 11 and 260 of Human HLA-DPA1.
HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DP alpha 1 chain; DP alpha chain; DP(W3); DP(W4); HLA class II histocompatibility antigen; HLA class II histocompatibility antigen, DP alpha 1 chain; HLA-DP1A; HLA-SB alpha chain; HLADP; HLASB; MHC class II antigen; MHC class II DP3-alpha; MHC class II DPA1; MHC class II HLA-DPA1 antigen; PLT1; Primed lymphocyte test-1
Gene Aliases: DP(W3); DP(W4); HLA-DP1A; HLA-DPA1; HLADP; HLASB; PLT1
UniProt ID: (Human) P20036
Entrez Gene ID: (Human) 3113
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