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          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • HMGCR Antibodies

          Invitrogen

          HMGCR Polyclonal Antibody

          View all (18) HMGCR antibodies

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          Cite HMGCR Polyclonal Antibody

          • Antibody Testing Data (10)
          HMGCR Antibody in Immunocytochemistry (ICC/IF)
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          HMGCR Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          FIGURE: 1 / 10

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          HMGCR Antibody (PA5-116675) in ICC/IF

          Immunofluorescence analysis of HMGCR in NIH/3T3 cells. Samples were incubated with HMGCR Polyclonal antibody (Product # PA5-116675) using a dilution of 1:200 (40x lens). Blue: DAPI for nuclear staining. {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          HMGCR Antibody in Immunocytochemistry (ICC/IF)
          HMGCR Antibody in Immunocytochemistry (ICC/IF)
          HMGCR Antibody in Immunocytochemistry (ICC/IF)
          HMGCR Antibody in Immunocytochemistry (ICC/IF)
          HMGCR Antibody in Immunocytochemistry (ICC/IF)
          HMGCR Antibody in Immunocytochemistry (ICC/IF)
          HMGCR Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          HMGCR Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          HMGCR Antibody in Western Blot (WB)
          HMGCR Antibody in Western Blot (WB)

          Product Details

          PA5-116675

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:4,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:100
          -

          Immunocytochemistry (ICC/IF)

          1:50-1:200
          -

          ELISA (ELISA)

          1 µg/mL
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthetic peptide corresponding to a sequence within amino acids 731-830 of human HMGCR (NP_0008501)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          0.21 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.3, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C, Avoid Freeze/Thaw Cycles

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2901306

          Product Specific Information

          Positive Samples: Mouse spleen, Rat brain

          Immunogen sequence: ASGPTNEDL

          Target Information

          3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; MGC103269

          View more View less

          Gene Aliases: 3H3M; HMG-CoAR; HMGCR; LDLCQ3; Red

          View more View less

          UniProt ID: (Human) P04035, (Mouse) Q5U4I2, (Rat) P51639

          View more View less

          Entrez Gene ID: (Human) 3156, (Mouse) 15357, (Rat) 25675

          View more View less

          Function(s)
          hydroxymethylglutaryl-CoA reductase (NADPH) activity protein binding hydroxymethylglutaryl-CoA reductase activity protein homodimerization activity coenzyme binding protein phosphatase 2A binding NADPH binding oxidoreductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor NADP binding oxidoreductase reductase metabolite interconversion enzyme
          Process(es)
          cholesterol biosynthetic process ubiquinone metabolic process aging response to nutrient isoprenoid biosynthetic process visual learning negative regulation of striated muscle cell apoptotic process positive regulation of cardiac muscle cell apoptotic process coenzyme A metabolic process positive regulation of stress-activated MAPK cascade negative regulation of MAP kinase activity myoblast differentiation response to ethanol negative regulation of vasodilation positive regulation of skeletal muscle tissue development positive regulation of smooth muscle cell proliferation protein tetramerization oxidation-reduction process negative regulation of wound healing negative regulation of insulin secretion involved in cellular response to glucose stimulus positive regulation of ERK1 and ERK2 cascade lipid metabolic process steroid biosynthetic process steroid metabolic process cholesterol metabolic process positive regulation of cell proliferation embryo development sterol biosynthetic process negative regulation of apoptotic process farnesyl diphosphate biosynthetic process, mevalonate pathway
          It has to be done as per old AB suggested Products section.
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          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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