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Invitrogen
HNF1A Polyclonal Antibody
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Product Details
PA5-83263
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human HNF1A. Recombinant protein control fragment (Product #RP-102658).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Amount
20 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: VYNWFANRRK EEAFRHKLAM DTYSGPPPGP GPGPALPAHS SPGLPPPALS PSKVHGVRYG QPATSETAEV PSSSGG
Highest antigen sequence indentity to the following orthologs: Mouse - 92%, Rat - 92%.
Target Information
This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: albumin proximal factor; hepatic nuclear factor 1; Hepatocyte nuclear factor 1-alpha; hnf-1 alpha; HNF-1-alpha; interferon production regulator factor; LFB1; Liver-specific transcription factor LF-B1; TCF-1; transcription factor; Transcription factor 1; transcription factor 1, hepatic; unnamed protein product
Gene Aliases: HNF-1-alpha; HNF-1A; HNF1; HNF1A; HNF1alpha; HNF4A; IDDM20; LFB1; MODY3; TCF-1; TCF1
UniProt ID: (Human) P20823
Entrez Gene ID: (Human) 6927
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
protein homodimerization activity
protein heterodimerization activity
protein dimerization activity
liver development
regulation of transcription from RNA polymerase II promoter
insulin secretion
pancreas development
regulation of pronephros size
renal glucose absorption
glucose homeostasis
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
glucose import
positive regulation of transcription initiation from RNA polymerase II promoter
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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