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Invitrogen
HNF6 Polyclonal Antibody
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FIGURE: 1 / 3
HNF6 Antibody (PA5-79770) in WB
Western blot was performed using Anti-HNF6 Polyclonal Antibody(Product # PA5-79770) and a 52 kDa band corresponding to HNF6 was observed across the cell lines and tissues tested. Whole cell extracts of Hep G2 (Lane 1), SK-O-V3 (Lane 2), NIH: OVCAR-3 (Lane 3), HeLa (Lane 4), Mouse Liver (Lane 5), Rat Liver (Lane 6) and Mouse Heart (Lane 7) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a Nitrocellulose membrane (Product # LC2001) by iBlot® 2 Dry Blotting Syst... View More
Product Details
PA5-79770
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human HNF6 (187-203aa LGSIHNSQQGLPHYAHP).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5mg BSA
Contains
0.01mg sodium azide, 0.05mg thimerosal
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human HepG2 whole cell, human HUH7 whole cell, rat liver tissue, rat RH35 whole cell, mouse liver tissue .
Target Information
Hepatocyte nuclear factor 6 is a CUT homeobox family protein which is a transcription factor and contains a CUT DNA-binding domain and a homeobox DNA-binding domain. It is an upstream regulator of several genes involved in the pathogenesis of maturity-onset diabetes of the young. HNF6 is a ligand of the FOXM1 transcription factor network. HNF6, along with HNF4, controls gene expression in the liver. The expression levels of HNF6 and HNF4 rise steadily during development and that up- or down regulation of HNF6 and HNF4 expression generate premature or delayed expression of the g6pc gene.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hepatic nuclear factor 6; Hepatocyte nuclear factor 6; hepatocyte nuclear factor 6, alpha; HNF-3/forkhead homolog 12; HNF-6; One cut domain family member 1; one cut domain, family member 1; One cut homeobox 1; transcription factor
Gene Aliases: D9Ertd423e; Hfh12; HNF-6; HNF6; HNF6A; Hnf6b; OC-1; Oc1; ONECUT1
UniProt ID: (Human) Q9UBC0, (Mouse) O08755, (Rat) P70512
Entrez Gene ID: (Human) 3175, (Mouse) 15379, (Rat) 25231
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
sequence-specific double-stranded DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
homeodomain transcription factor
liver development
regulation of cell-matrix adhesion
epithelial cell development
type B pancreatic cell differentiation
pancreatic A cell differentiation
pancreatic D cell differentiation
glucose metabolic process
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
transforming growth factor beta receptor signaling pathway
Notch signaling pathway
endoderm development
anatomical structure morphogenesis
cell migration
B cell differentiation
positive regulation of cell migration
negative regulation of transforming growth factor beta receptor signaling pathway
pancreas development
endocrine pancreas development
enteroendocrine cell differentiation
cell fate commitment
positive regulation of transcription from RNA polymerase II promoter
spleen development
cilium morphogenesis
transcription, DNA-templated
transcription from RNA polymerase II promoter
cell differentiation
cilium assembly
system development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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