In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. The encoded protein may be involved in the placement of hindbrain segments in the proper location along the anterior-posterior axis during development. Two transcript variants encoding two different isoforms have been found for this gene, with only one of the isoforms containing the homeodomain region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: homeo box A1; homeobox 1F; Homeobox protein Hox-1F; Homeobox protein Hox-A1; Hox 1.6-like protein; HOX A1 homeodomain protein; HOXA 1; HOXA-1; lab-like protein; MGC45232
Gene Aliases: BSAS; HOX1; HOX1F; HOXA1
UniProt ID: (Human) P49639
Entrez Gene ID: (Human) 3198