Immunogen sequence: EVTFREYAIE PATKWHPRGN LAHCYSAEEL VHRDCLQAPS AAGVPGDVLA KSSANVYHHP TPAVSSNFY
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t(10:14)(q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.
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Protein Aliases: homeo box 1I; Homeobox protein Hox-1I; Homeobox protein Hox-A11; homeobox protein HOXA11; HOX11
Gene Aliases: HOX1; HOX1I; HOXA11; RUSAT1
UniProt ID: (Human) P31270
Entrez Gene ID: (Human) 3207