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Invitrogen

HOXA11 Polyclonal Antibody

Advanced Verification

This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated.

View all (10) HOXA11 antibodies
Datasheet
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

PA5-57341

Applications Tested Dilution Publications

Western Blot (WB)

 0.04-0.4 µg/mL -

Immunohistochemistry (IHC)

 1:200-1:500 -
Product Specifications

Species Reactivity

 Human

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

Recombinant protein corresponding to Human HOXA11
View immunogen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 0.5 mg/mL

Purification

 Antigen affinity chromatography

Storage buffer

 PBS, pH 7.2, with 40% glycerol

Contains

 0.02% sodium azide

Storage conditions

 Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

RRID

AB_2642519

Product Specific Information

Immunogen sequence: EVTFREYAIE PATKWHPRGN LAHCYSAEEL VHRDCLQAPS AAGVPGDVLA KSSANVYHHP TPAVSSNFY

Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

Target Information

HOX11, also called homeobox11 or Tcl-3 is located at the 10q24 T-Cell translocation breakpoint region. It encodes a homeobox-domain containing protein, HOX11, containing a glycine and proline-rich amino terminus. HOX11 is required for maintenance of the developing spleen and cell survival. The HOX11protein binds to a specific DNA sequence and localizes to the cell nucleus. It transactivates transcription of a reporter gene linked to a cis-regulatory element, acting as a positive transcription activator. The HOX11 gene is highly expressed in T-ALLs as a result of a t (7:10) (q35;q24) or t (10:14) (q24;qll) translocation. The homeobox gene is deregulated upon translocation into the T-cell receptor locus and activates a specific subset of tumor-associated target genes. HOX 11 gene translocation has been attributed to T-cell leukemia and lymphoid neoplasias.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: homeo box 1I; Homeobox protein Hox-1I; Homeobox protein Hox-A11; homeobox protein HOXA11; HOX11

Gene Aliases: HOX1; HOX1I; HOXA11; RUSAT1

UniProt ID: (Human) P31270

Entrez Gene ID: (Human) 3207

Molecular Function: homeodomain transcription factor

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