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Invitrogen
HOXA13 Polyclonal Antibody
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Product Details
PA5-76440
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein of human HOXA13.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Target Information
HoxA13 and HoxD13 also bind to other BMP and TGF-beta/Activin-regulated Smad proteins including Smad1 and Smad2, but not Smad4. In humans and mice, loss of HOXA13 function causes defects in the growth and patterning of the digits and interdigital tissues. Analysis of HoxA13 expression reveals a pattern of localization overlapping with sites of reduced Bmp2 and Bmp7 expression in HoxA13 mutant limbs. HoxA13 regulates Bmp2 and Bmp7 expression, providing a link between HoxA13, its target genes and the specific developmental processes affected by loss of HoxA13 function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: homeo box 1J; homeo box A13; homeobox A13; Homeobox protein Hox-1.10; Homeobox protein Hox-1J; Homeobox protein Hox-A13; homeobox protein HOXA13; hypodactyly; transcription factor HOXA13
Gene Aliases: Hd; Hox-1.10; HOX1; HOX1J; HOXA13; RGD1562483
UniProt ID: (Human) P31271, (Mouse) Q62424
Entrez Gene ID: (Human) 3209, (Rat) 500129, (Mouse) 15398
transcription regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
sequence-specific double-stranded DNA binding
molecular_function
protein binding
transcription regulatory region DNA binding
regulation of transcription, DNA-templated
embryonic hindgut morphogenesis
vasculogenesis
endothelial cell morphogenesis
tissue homeostasis
ventricular septum development
transcription, DNA-templated
multicellular organism development
anatomical structure morphogenesis
organ morphogenesis
regulation of BMP signaling pathway
male genitalia development
embryonic forelimb morphogenesis
positive regulation of mitotic nuclear division
positive regulation of transcription from RNA polymerase II promoter
inner ear development
artery morphogenesis
branching involved in prostate gland morphogenesis
endothelial cell fate specification
positive regulation of mesenchymal cell apoptotic process
skeletal system development
regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
prostate gland development
response to testosterone
mesenchymal cell apoptotic process
mitotic nuclear division
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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