In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. HOXA5 gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.
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Protein Aliases: homeo box 1C; homeo box A5; Homeobox protein Hox-1.3; Homeobox protein Hox-1C; Homeobox protein Hox-A5; homeobox protein HOXA5; Homeobox protein M2; hox-1.3; Hox-1C
Gene Aliases: Hox-1.3; HOX1; HOX1.3; HOX1C; Hoxa-5; HOXA5
Molecular Function: homeodomain transcription factor