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|Tested species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminal region of the human HOXB7 (homeobox B7, homeobox C1) protein|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
|Western Blot (WB)||See 1 publications below|
The homeobox genes encode transcription factors that regulate developmental processes such as body patterning and organogenesis. The mammalian HOX gene complex consists of 39 genes that are located on 4 linkage groups (clusters), dispersed over 4 chromosomes (HOXA, HOXB, HOXC and HOXD). HOXB7 is expressed in most malignant T-cell lines and CD4-positive peripheral blood cells, and is constitutively expressed in both melanoma primary lesions and cell lines. HOXB7 binds to and transactivates bFGF in melanoma cell lines but SkBr3 breast adenocarcinoma is negative for the expression of both HOXB7 and bFGF genes. HOXB7 may be a key activator of tumor-associated neoangiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
|Human||1:125||HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients.||Storti P,Donofrio G,Colla S,Airoldi I,Bolzoni M,Agnelli L,Abeltino M,Todoerti K,Lazzaretti M,Mancini C,Ribatti D,Bonomini S,Franceschi V,Pistoia V,Lisignoli G,Pedrazzini A,Cavicchi O,Neri A,Rizzoli V,Giuliani N||Leukemia (25:527)||2011|
homeo box 2C; homeo box B7; homeo box c1 protein; homeobox protein HHO.C1; homeobox protein Hox-2C; HOX2C; HOXB7
HHO.C1; Hox-2.3; HOX2; HOX2C; HOXB7