|Tested species reactivity||Human|
|Published species reactivity||Human, Not Applicable|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide derived from the C-terminal region of the human HOXB7 (homeobox B7, homeobox C1) protein|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.4|
|Contains||0.1% sodium azide|
|Tested Applications||Dilution *|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
The homeobox genes encode transcription factors that regulate developmental processes such as body patterning and organogenesis. The mammalian HOX gene complex consists of 39 genes that are located on 4 linkage groups (clusters), dispersed over 4 chromosomes (HOXA, HOXB, HOXC and HOXD). HOXB7 is expressed in most malignant T-cell lines and CD4-positive peripheral blood cells, and is constitutively expressed in both melanoma primary lesions and cell lines. HOXB7 binds to and transactivates bFGF in melanoma cell lines but SkBr3 breast adenocarcinoma is negative for the expression of both HOXB7 and bFGF genes. HOXB7 may be a key activator of tumor-associated neoangiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
The roles of HOXB7 in promoting migration, invasion, and anti-apoptosis in gastric cancer.
40-2000 was used in western blot to study promotion of invasion, migration and anti-apoptosis in gastric cancer and the role of HOXB7
|Joo MK,Park JJ,Yoo HS,Lee BJ,Chun HJ,Lee SW,Bak YT||Journal of gastroenterology and hepatology (31:1717)||2016|
|Human||1:125||HOXB7 expression by myeloma cells regulates their pro-angiogenic properties in multiple myeloma patients.||Storti P,Donofrio G,Colla S,Airoldi I,Bolzoni M,Agnelli L,Abeltino M,Todoerti K,Lazzaretti M,Mancini C,Ribatti D,Bonomini S,Franceschi V,Pistoia V,Lisignoli G,Pedrazzini A,Cavicchi O,Neri A,Rizzoli V,Giuliani N||Leukemia (25:527)||2011|
HOXB7-S3 inhibits the proliferation and invasion of MCF-7 human breast cancer cells.
40-2000 was used in western blot to determine the effects of HOXB7 on the proliferation and invasion of breast cancer cells.
|Ma R,Zhang D,Hu PC,Li Q,Lin CY||Molecular medicine reports (12:4901)||2015|