Immunogen sequence: MSFPNSSPAA NTFLVDSLIS ACRSDSFYSS SASMYMPPPS ADMGTYGMQT CGLLPSLAKR EVNHQNMGMN VHPYIPQVDS WTDPNRSCRI EQPVTQQVPT CSFTTNIKEE SNCCMYSDKR NKLISAEVPS YQRLVPESCP VENPEVPVPG YFRLSQTYAT GKTQEYNNSP EGSSTVMLQL NPRGAAKPQL SAAQLQMEKK MNEPVSGQEP TKVSQVESPE AKGGLPEERS CLAEVSVSSP; Positive Samples: Mouse kidney, Mouse heart, Rat heart; Cellular Location: Nucleus
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
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Protein Aliases: homeo box 4D; homeo box D10; Homeobox protein Hox-4.5; Homeobox protein Hox-4D; Homeobox protein Hox-4E; Homeobox protein Hox-5.3; Homeobox protein Hox-D10
Gene Aliases: AI385591; AI874987; Hox-4.4; Hox-4.5; Hox-5.3; HOX4; HOX4D; HOX4E; Hoxd-10; HOXD10