Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 93%; Zebrafish: 86%
The protein is a transferase, which catalyzes conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate via transfer of the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate. This enzyme plays a central role in the generation of purine nucleotides through the purine salvage pathway.
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Protein Aliases: HGPRT; HGPRTase; HPRT B; hypoxanthine guanine phosphoribosyl transferase 1; Hypoxanthine-guanine phosphoribosyltransferase
Gene Aliases: C81579; HPGRT; Hprt; Hprt1
UniProt ID: (Mouse) P00493
Entrez Gene ID: (Mouse) 15452