Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:22825852). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777, PubMed:22825852). [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ca(2+)-independent N-acyltransferase; Ca-independent N-acyltransferase; calcium-independent phosphatidylethanolamine N-acyltransferase; H-rev107-like protein 5; HRAS-like suppressor 5; HRAS-like suppressor family, member 5; HRSL5; iNAT; lecithin-retinol acyltransferase (LRAT)-like protein-1; Phospholipase A and acyltransferase 5; testicular tissue protein Li 90
Gene Aliases: 1700055A14Rik; 1700086E08Rik; 4921526K24Rik; HRASLS5; HRLP5; HRSL5; iNAT; PLAAT5; RGD1308376; RLP1