Immunogen sequence: HSHESQDLRV IDFNCTTSSV SSALANTKDS PVLIDFFEDT ERYRKQANKA LEKYKEENDD FASFRVDRIE RVARVRGG
Highest antigen sequence identity to the following orthologs: Mouse - 76%, Rat - 71%.
HRG contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.
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Protein Aliases: DKFZp779H1622; Histidine-proline-rich glycoprotein; Histidine-rich glycoprotein; HPRG
Gene Aliases: HPRG; HRG; HRGP; THPH11
UniProt ID: (Human) P04196
Entrez Gene ID: (Human) 3273