Search
Invitrogen
HRG Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
FIGURE: 1 / 1
HRG Antibody (PA5-97051) in WB
Western blot analysis of HRG in extracts of mouse pancreas. Samples were incubated with HRG Polyclonal antibody (Product # PA5-97051) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.
Product Details
PA5-97051
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-260 of human HRG (NP_0004031)
Conjugate
Form
Liquid
Concentration
1.78 mg/mL
Amount
178 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: SPTDCSAVEP EAEKALDLIN KRRRDGYLFQ LLRIADAHLD RVENTTVYYL VLDVQESDCS VLSRKYWNDC EPPDSRRPSE IVIGQCKVIA TRHSHESQDL RVIDFNCTTS SVSSALANTK DSPVLIDFFE DTERYRKQAN KALEKYKEEN DDFASFRVDR IERVARVRGG EGTGYFVDFS VRNCPRHHFP RHPNVFGFCR ADLFYDVEAL DLESPKNLVI NCEVFDPQEH ENINGVPPHL G; Positive Samples: Mouse pancreas
Target Information
HRG contains two cystatin-like domains and is located in plasma and platelets. The physiological function has not been determined but it is known that the protein binds heme, dyes and divalent metal ions. It can inhibit rosette formation and interacts with heparin, thrombospondin and plasminogen. Two of the protein's effects, the inhibition of fibrinolysis and the reduction of inhibition of coagulation, indicate a potential prothrombotic effect. Mutations in this gene lead to thrombophilia due to abnormal histidine-rich glycoprotein levels.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: DKFZp779H1622; Histidine-proline-rich glycoprotein; Histidine-rich glycoprotein; Histidine-rich glycoprotein 1; HPRG; HRG1
Gene Aliases: AI265597; AW413091; D16jh2; D18020; HPRG; Hrg; HRG1; Hrgp
UniProt ID: (Rat) Q99PS8, (Mouse) Q9ESB3
Entrez Gene ID: (Rat) 171016, (Mouse) 94175
positive regulation of immune response to tumor cell
negative regulation of cell adhesion
biological_process
negative regulation of cell proliferation
regulation of gene expression
regulation of platelet activation
negative regulation of lamellipodium assembly
negative regulation of endopeptidase activity
response to organic cyclic compound
heme transport
negative regulation of angiogenesis
platelet activation
regulation of blood coagulation
negative regulation of cell growth
regulation of actin cytoskeleton organization
negative regulation of cell adhesion mediated by integrin
regulation of transcription from RNA polymerase II promoter in response to iron
fibrinolysis
positive regulation of apoptotic process
regulation of protein complex assembly
negative regulation of blood vessel endothelial cell migration
regulation of peptidyl-tyrosine phosphorylation
defense response to fungus
positive regulation of focal adhesion assembly
negative regulation of fibrinolysis
heme export
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of blood vessel remodeling
negative regulation of endothelial cell chemotaxis
angiogenesis
chemotaxis
blood coagulation
hemostasis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support