Bioss

HRG beta 1 Polyclonal Antibody

View all (3) HRG beta-1 antibodies
Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

BS-6228R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:400
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human NRG1, amino acids 65-150.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: acetylcholine receptor-inducing activity; glial growth factor 2; heregulin; heregulin, alpha (45kD, ERBB2 p185-activator); neu differentiation factor; neuregulin 1 type III beta 3; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1; sensory and motor neuron derived factor; type I neuregulin 1; type III neuregulin 1

View more View less

Gene Aliases: 6030402G23Rik; ARIA; D230005F13Rik; GGF; GGF2; GGFII; HGL; HRG; HRG1; HRGA; HRGalpha; MST131; MSTP131; NDF; NRG1; NRG1-IT2; SMDF

View more View less

UniProt ID: (Human) A5YAK4

View more View less

Entrez Gene ID: (Human) 3084, (Rat) 112400, (Mouse) 211323

View more View less

Function(s)
transcription cofactor activity protein tyrosine kinase activity Ras guanyl-nucleotide exchange factor activity cytokine activity ErbB-2 class receptor binding integrin binding growth factor activity transmembrane receptor protein tyrosine kinase activator activity receptor tyrosine kinase binding ErbB-3 class receptor binding chemorepellent activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity receptor binding protein tyrosine kinase activator activity growth factor
Process(es)
MAPK cascade activation of MAPK activity cell morphogenesis startle response cardiac conduction system development ventricular trabecula myocardium morphogenesis cell communication activation of transmembrane receptor protein tyrosine kinase activity nervous system development synapse assembly peripheral nervous system development locomotory behavior regulation of blood pressure positive regulation of cell proliferation embryo development neural crest cell development regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling glucose transport peptidyl-tyrosine phosphorylation glial cell fate commitment chemorepulsion involved in interneuron migration from the subpallium to the cortex mammary gland development positive regulation of myelination activation of protein kinase B activity intracellular signal transduction ERBB signaling pathway ERBB2 signaling pathway wound healing negative regulation of protein catabolic process myelination regulation of protein homodimerization activity regulation of protein heterodimerization activity positive regulation of GTPase activity neurotransmitter receptor metabolic process positive regulation of axon extension negative regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of Ras protein signal transduction phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling neuron fate commitment oligodendrocyte differentiation positive regulation of peptidyl-tyrosine phosphorylation negative regulation of secretion positive regulation of striated muscle cell differentiation positive regulation of protein kinase B signaling cardiac muscle cell differentiation cardiac muscle cell myoblast differentiation endocardial cell differentiation positive regulation of dendritic spine development positive regulation of calcineurin-NFAT signaling cascade positive regulation of protein targeting to mitochondrion positive regulation of protein localization to cell surface regulation of cell motility positive regulation of cardiac muscle cell differentiation negative regulation of neuron migration transmembrane receptor protein tyrosine kinase signaling pathway heart development muscle organ development cell proliferation glial cell differentiation negative regulation of cardiac muscle cell apoptotic process cell migration cell differentiation positive regulation of cell growth cellular protein complex disassembly regulation of cell differentiation positive regulation of cell adhesion positive regulation of protein kinase activity animal organ development ventricular cardiac muscle cell differentiation positive regulation of cardiac muscle cell proliferation positive regulation of protein tyrosine kinase activity negative regulation of extrinsic apoptotic signaling pathway in absence of ligand axon ensheathment
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support