Immunogen sequence: VRFSRCVLL NYWKVLPKSF LRSMGQWAVI TGAGDGIGKA YSFELAKRGL NVVLISRTLE KLEAIATEIE RTTGRSVKII QADFTKDDIY EHIKEKLAGL EIGILVNNVG MLPNLLPSHF LNAPDEIQSL IHCNITSVVK MTQLILKHME SRQK (25-177 aa encoded by BC034281)
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
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Protein Aliases: 17(beta)HSD type 3; 17-beta-HSD 3; 17-beta-HSD3; 17-beta-hydroxysteroid dehydrogenase type 3; 17beta-HSD; estradiol 17 beta-dehydrogenase 3; Estradiol 17-beta-dehydrogenase 2; hydroxysteroid (17-beta) dehydrogenase 3; hydroxysteroid dehydrogenase 3; Short chain dehydrogenase/reductase family 12C member 2; short chain dehydrogenase/reductase family 12C, member 2; Testicular 17-beta-hydroxysteroid dehydrogenase; Testosterone 17-beta-dehydrogenase 3
Gene Aliases: EDH17B3; HSD17B3; SDR12C2