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Agrisera

HSP70/HSC70/Heat shock protein 70 Polyclonal Antibody

View all (64) HSP70 antibodies

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Product Details

AS09-592

Applications
Tested Dilution
Publications

Western Blot (WB)

1:10,000
-
Product Specifications

Species Reactivity

Amphibian, Bovine, C. elegans, Chicken, Fish, Mycetozoan, Plant, Pig, Protozoa, Rat

Host/Isotype

Rabbit

Class

Polyclonal

Type

Antibody

Immunogen

KLH-conjugated C-terminal synthetic peptide conserved in hsc/hsp70 sequences from a wide range of animal species.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Storage buffer

whole serum

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store lyophilized/reconstituted at -20°C; once reconstituted make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube.

For reconstitution add 200 µL of sterile water.

Specific Species Reactivity: Arabidopsis thaliana, Acanthamoeba castellanii (amoeba), Caenorhabditis elegans, salmon (Salmo salar), Dictyostelium discoideum, frog-heart, Frog-skeletal muscle, Frog-liver, rainbow trout (Oncorhynchus mykiss), cow, Chicken, pig, Rat, seal, mummichog

Target Information

HSP70 is a Heat shock protein (HSP) which are expressed in response to various biological stresses, including high temperatures. There are several major families of HSPs that include HSP70, there are HSP90 and HSP100. The HSP70 family is a set of highly conserved proteins that are induced by a variety of biological stresses, including heat stress, in every organism in which the proteins have been examined. The human HSP70 family members include: HSP70, a protein which is strongly inducible in all organisms but which is also constitutively expressed in primate cells; HSP72, a 72 kDa protein that is induced exclusively under stress conditions; HSC70, or cognate protein, is a 72 kDa, constitutively expressed, protein which is involved in the uncoating of clathrin coated vesicles; GRP78, or BiP, is a glucose regulated 78 kDa protein localized in the endoplasmic reticulum; and p75, or HSP75, a 75 kDa protein that is found within the mitochondria. Further, HSP70 is encoded by an intronless gene and, in conjunction with other heat shock proteins, HSP70 stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and organelles. HSP70 is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The HSP70 gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 70 kda heat shock protein-2; 70 kilodalton heat shock protein; ARABIDOPSIS HEAT SHOCK PROTEIN 70; ATHSP70; chaperone; heat shock 10kDa protein 1-like; heat shock 70 kD protein 1; heat shock 70 kD protein 2; heat shock 70 kD protein 3; Heat shock 70 kDa protein 1; Heat shock 70 kDa protein 1-like; heat shock 70 kDa protein 1/2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1A/1B; Heat shock 70 kDa protein 1B; Heat shock 70 kDa protein 1L; Heat shock 70 kDa protein 2; Heat shock 70 kDa protein 3; Heat shock 70 kDa protein 4; heat shock 70kD protein 1B; heat shock 70kDa protein 1-like; heat shock 70kDa protein 1A; heat shock 70kDa protein 1B; heat shock 70kDa protein 2; heat shock 70kDa protein 3; heat shock 70kDa protein 4; Heat shock protein; Heat Shock Protein 70; heat shock protein 70-1; Heat shock protein 70-1l; Heat shock protein 70.2; heat shock protein alpha 2; Heat shock-related 70 kDa protein 2; heat-shock 70-kilodalton protein 1A; heat-shock 70-kilodalton protein 1B; HEL S 103; HSP; HSP70 1; HSP70 1B; HSP70 2; HSP70 AceyltK77; HSP70-1; HSP70-1/HSP70-2; HSP70-2; HSP70.1; HSP70.1/2; HSP70.1/HSP70.2; HSP70.2; HSP70.3; HSPA2; HSPA4; Hspa70; HST; Ischemia responsive 94 kDa protein; Testis-specific heat shock protein-related; testis-specific heat shock protein-related gene hst70

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Gene Aliases: CELE_C12C8.1; Hsp110; HSP70; HSP70-1; HSP70-2; HSP70-3; HSP72; HSPA1; HSPA1A; HSPA1B; HSPA1L; HSPA2; HSPA3; Hspa4; Hsph2; Hspt70; Hst70; Irp94

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UniProt ID: (Pig) Q6S4N2, (Bovine) Q27975, (Pig) A5A8V7, (Bovine) P0CB32, (Bovine) P34933, (Rat) P0DMW0, (Rat) P55063, (Rat) P14659, (Rat) O88600

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Entrez Gene ID: (Pig) 396648, (Bovine) 282254, (Pig) 100144518, (Bovine) 540190, (Bovine) 281827, (Pig) 100621324, (Pig) 100524853, (Chicken) 416339, (Bovine) 536558, (Rat) 24472, (Rat) 294254, (Rat) 24963, (Rat) 60460, (Rat) 266759, (C. elegans) 172757

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Function(s)
ATP binding G-protein coupled receptor binding protease binding double-stranded RNA binding protein binding ATPase activity enzyme binding heat shock protein binding ubiquitin protein ligase binding ATPase activity, coupled protein binding involved in protein folding poly(A) RNA binding protein N-terminus binding NF-kappaB binding unfolded protein binding molecular_function glycolipid binding RNA polymerase II transcription factor binding protein complex binding activating transcription factor binding nucleotide binding misfolded protein binding
Process(es)
binding of sperm to zona pellucida biological_process protein refolding spermatogenesis response to heat response to cold cell differentiation response to unfolded protein determination of adult lifespan endoplasmic reticulum unfolded protein response cellular response to unfolded protein IRE1-mediated unfolded protein response chaperone mediated protein folding requiring cofactor telomere maintenance response to ischemia DNA repair mRNA catabolic process negative regulation of cell proliferation response to radiation response to mechanical stimulus regulation of cell death neuron differentiation negative regulation of cell growth negative regulation of protein ubiquitination cellular response to heat negative regulation of apoptotic process response to ethanol positive regulation of erythrocyte differentiation positive regulation of neuron differentiation negative regulation of cell death cellular heat acclimation negative regulation of inclusion body assembly negative regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of protein targeting to mitochondrion kidney development negative regulation of protein phosphorylation positive regulation of gene expression negative regulation of gene expression positive regulation of protein binding negative regulation of DNA binding protein import into mitochondrial outer membrane positive regulation of angiogenesis chaperone-mediated protein complex assembly positive regulation of microtubule nucleation regulation of mitotic spindle assembly positive regulation of protein phosphorylation male meiosis male meiosis I multicellular organism development spermatid development positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle synaptonemal complex disassembly positive regulation of T cell mediated cytotoxicity defense response negative regulation of myeloid cell apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of vasoconstriction
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