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Proteintech
HSPA4 Polyclonal Antibody
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Product Details
21206-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
HSPA4 Fusion Protein Ag15581 (680-840 aa encoded by BC110861)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Amount
27 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody well recognized the endogenous HSPA4 protein in mouse brain/ testis tissues.
Immunogen sequence: NLGQPIKIR FQESEERPKL FEELGKQIQQ YMKIISSFKN KEDQYDHLDA ADMTKVEKST NEAMEWMNNK LNLQNKQSLT MDPVVKSKEI EAKIKELTST CSPIISKPKP KVEPPKEEQK NAEQNGPVDG QGDNPGPQAA EQGTDTAVPS DSDKKLPEMD ID (680-840 aa encoded by BC110861)
Target Information
The HSP 70 family is composed of four highly conserved proteins: HSP 70, HSC 70, GRP 75 and GRP 78. HSP 70 expression is strongly induced in response to heat stress. HSP 70 and HSC 70 play key roles in the cytosolic endoplasmic reticulum and mitochondrial import machinery and are found in both the cytosol and nucleus of mammalian cells. GRP 78 is localized in the endoplasmic reticulum, where it receives imported secretory proteins and is involved in the folding and translocation of nascent peptide chains. GRP 75 expression is restricted to the mitochondrial matrix and aids in the translocation and folding of nascent polypeptide chains of both nuclear and mitochondrial origin. It has been postulated that members of the HSP 70 family act as force-generating motors, relying on the hydrolysis of ATP for their activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: epididymis secretory sperm binding protein Li 5a; Heat shock 70 kDa protein 4; Heat shock 70-related protein APG-2; heat shock 70kD protein 4; Heat shock protein; Heat shock protein family H member 2; heat shock protein, 110 kDa; hsp70 RY; HSP70RY; Ischemia responsive 94 kDa protein; unnamed protein product
Gene Aliases: 70kDa; AI317151; APG-2; APG2; HEL-S-5a; HS24/P52; Hsp110; Hsp70; Hsp70RY; HSPA4; HSPH2; Irp94; mKIAA4025; RY
UniProt ID: (Human) P34932, (Rat) O88600
Entrez Gene ID: (Human) 3308, (Mouse) 15525, (Rat) 266759
negative regulation of protein phosphorylation
response to heat
positive regulation of gene expression
negative regulation of gene expression
positive regulation of protein binding
negative regulation of apoptotic process
negative regulation of DNA binding
protein import into mitochondrial outer membrane
chaperone-mediated protein complex assembly
negative regulation of cell death
protein folding
response to unfolded protein
protein import into mitochondrial matrix
kidney development
positive regulation of angiogenesis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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