The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.
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Protein Aliases: cofactor required for Tat activation of HIV-1 transcription; HIV TAT specific factor 1; HIV Tat-specific factor 1; HIV Tat-specific factor 1 homolog; Tat-SF1
Gene Aliases: 1600023H17Rik; 2600017A12Rik; 2700077B20Rik; dJ196E23.2; HTATSF1; RGD1563377; TAT-SF1; TATSF1