Immunogen sequence: GKDGDTQTDA GGEPDSLGQQ PTDTPYEWDL DKKAWFPKIT EDFIATYQAN YGFSNDGASS STANVEDVHA RTAEEPPQEK APEPTDARKK GEKRKAESGW FHVEEDRNTN VYVSGLPPDI TVDE
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 79%.
The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.
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Protein Aliases: cofactor required for Tat activation of HIV-1 transcription; HIV TAT specific factor 1; HIV Tat-specific factor 1; RP1-196E23.2; Tat-SF1
Gene Aliases: dJ196E23.2; HTATSF1; TAT-SF1; TATSF1
UniProt ID: (Human) O43719
Entrez Gene ID: (Human) 27336