Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey (100%) Marmoset, Bat (95%) Horse (90%).
HTR2B is a g-protein coupled receptor for 5-hydroxytryptamine (serotonin). It functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. HTR2B also plays a role in perception of pain, regulation of behavior. It is required to normal proliferation of embryonic cardiac myocytes and normal heart development.
Protein Aliases: 5-HT 2B receptor; 5-HT-2B; 5-HT2b receptor; 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled; 5-hydroxytryptamine 2B receptor; 5-hydroxytryptamine receptor 2B; 5-hydroxytryptamine receptor 2B variant b; 5HT2B Receptor; Serotonin receptor 2B
Gene Aliases: 5-HT(2B); 5-HT-2B; 5-HT2B; HTR2B
UniProt ID: (Human) P41595
Entrez Gene ID: (Human) 3357
Molecular Function: G-protein coupled receptor