Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Elephant, Horse, Pig (100%) Panda, Dog, Rabbit (95%) Bat, Bovine (90%).
This gene is a member of the family of serotonin receptors, which are G protein coupled receptors that stimulate cAMP production in response to serotonin (5-hydroxytryptamine). The gene product is a glycosylated transmembrane protein that functions in both the peripheral and central nervous system to modulate the release of various neurotransmitters. Multiple transcript variants encoding proteins with distinct C-terminal sequences have been described, but the full-length nature of some transcript variants has not been determined.
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Protein Aliases: 5-HT-4; 5-HT4; 5-HT4 receptor; 5-HT4R; 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled; 5-hydroxytryptamine 4 receptor; 5-hydroxytryptamine receptor 4; 5HT4 receptor; Cardiac 5-HT4 receptor; HTR4; Serotonin 4 receptor; Serotonin 5-HT-4 receptor; Serotonin 5-HT-4a receptor; Serotonin receptor 4
Gene Aliases: 5-HT4; 5-HT4R; HTR4
UniProt ID: (Human) Q13639
Entrez Gene ID: (Human) 3360