Percent identity with other species by BLAST analysis: Human (100%) Gorilla (94%) Gibbon (88%) Monkey (81%).
5-HT7 Receptor is a Serotonin Receptor with several functions, including regulation of the circadian rhythm and mediation of smooth-muscle relaxation in the vasculature and GI tract. This receptor has been implicated in depression, autistism, and other neuropsychiatric disorders. Three protein isoforms have been documented: isoform a: 445aa; isoform b: 432aa; isoform d: 479aa. 5-HT7 Receptor has been reported in aorta, brain, heart, placenta, small intestine, spleen, artery, and vessel. An EST has been isolated from a testis library.
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Protein Aliases: 5-HT-7; 5-HT-X; 5-HT7; 5-HT7 receptor; 5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled); 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled; 5-hydroxytryptamine 7 receptor; 5-hydroxytryptamine receptor 7; 5HT7; 5HT7 Receptor; HT7; HTR7; Serotonin 5-HT7 receptor; Serotonin receptor 7
Gene Aliases: 5-HT7; HTR7
UniProt ID: (Human) P34969
Entrez Gene ID: (Human) 3363