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HUS1 Polyclonal Antibody

HUS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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HUS1 Antibody (11223-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human colon cancer using 11223-1-AP (HUS1 antibody) at dilution of 1:50 (under 10x lens).

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Product Details

11223-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

HUS1 Fusion Protein Ag1744 (1-280 aa encoded by BC007013)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MKFRAKIVD GACLNHFTRI SNMIAKLAKT CTLRISPDKL NFILCDKLAN GGVSMWCELE QENFFNEFQM EGVSAENNEI YLELTSENLS RALKTAQNAR ALKIKLTNKH FPCLTVSVEL LSMSSSSRIV THDIPIKVIP RKLWKDLQEP VVPDPDVSIY LPVLKTMKSV VEKMKNISNH LVIEANLDGE LNLKIETELV CVTTHFKDLG NPPLASESTH EDRNVEHMAE VHIDIRKLLQ FLAGQQVNPT KALCNIVNNK MVHFDLLHED VSLQYFIPAL S (1-280 aa encoded by BC007013)

Target Information

The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

DNA damage-induced translocation of mitochondrial factor HIGD1A into the nucleus regulates homologous recombination and radio/chemo-sensitivity.

Oncogene

Chen B,Xu F,Gao Y,Hu G,Zhu K,Lu H,Xu A,Chen S,Wu L,Zhao G

Tue Mar 01 00:00:00 UTC 2022

Discovery and Validation of Novel Methylation Markers in Helicobacter pylori-Associated Gastric Cancer.

Disease markers

Wang H,Li NS,He C,Xie C,Zhu Y,Lu NH,Hu Y

Mon Mar 14 00:00:00 UTC 2022

Succinylation at a key residue of FEN1 is involved in the DNA damage response to maintain genome stability.

American journal of physiology. Cell physiology

Shi R,Wang Y,Gao Y,Xu X,Mao S,Xiao Y,Song S,Wang L,Tian B,Zhao Y,Hua Y,Xu H

Thu Oct 01 00:00:00 UTC 2020

HUS1 checkpoint clamp component (HUS1) is a potential tumor suppressor in primary hepatocellular carcinoma.

Molecular carcinogenesis

Zhou ZQ,Zhao JJ,Chen CL,Liu Y,Zeng JX,Wu ZR,Tang Y,Zhu Q,Weng DS,Xia JC

Tue Jan 01 00:00:00 UTC 2019

HUS1 checkpoint clamp component (HUS1) is a potential tumor suppressor in primary hepatocellular carcinoma.

Molecular carcinogenesis

Zhou ZQ,Zhao JJ,Chen CL,Liu Y,Zeng JX,Wu ZR,Tang Y,Zhu Q,Weng DS,Xia JC

Tue Jan 01 00:00:00 UTC 2019

HUS1 checkpoint clamp component (HUS1) is a potential tumor suppressor in primary hepatocellular carcinoma.

Molecular carcinogenesis

Zhou ZQ,Zhao JJ,Chen CL,Liu Y,Zeng JX,Wu ZR,Tang Y,Zhu Q,Weng DS,Xia JC

Tue Jan 01 00:00:00 UTC 2019

HUS1 checkpoint clamp component (HUS1) is a potential tumor suppressor in primary hepatocellular carcinoma.

Molecular carcinogenesis

Zhou ZQ,Zhao JJ,Chen CL,Liu Y,Zeng JX,Wu ZR,Tang Y,Zhu Q,Weng DS,Xia JC

Tue Jan 01 00:00:00 UTC 2019

SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress.

Journal of molecular cell biology

Xu X,Shi R,Zheng L,Guo Z,Wang L,Zhou M,Zhao Y,Tian B,Truong K,Chen Y,Shen B,Hua Y,Xu H

Mon Oct 01 00:00:00 UTC 2018

SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress.

Journal of molecular cell biology

Xu X,Shi R,Zheng L,Guo Z,Wang L,Zhou M,Zhao Y,Tian B,Truong K,Chen Y,Shen B,Hua Y,Xu H

Mon Oct 01 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: Checkpoint protein HUS1; hHUS1; HUS1 checkpoint homolog; HUS1 protein; hus1+-like protein

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Gene Aliases: hHUS1; HUS1

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UniProt ID: (Human) O60921

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Entrez Gene ID: (Human) 3364

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Function(s)

protein binding DNA metabolism protein

Process(es)

DNA damage checkpoint double-strand break repair via homologous recombination regulation of protein phosphorylation DNA replication DNA repair nucleotide-excision repair protein phosphorylation cellular response to DNA damage stimulus negative regulation of DNA replication response to UV embryo development intra-S DNA damage checkpoint mitotic DNA replication checkpoint meiotic DNA integrity checkpoint cellular response to ionizing radiation regulation of signal transduction by p53 class mediator

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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HUS1 Polyclonal Antibody

HUS1 Antibody (11223-1-AP) in IHC (P)

Product Details

11223-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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