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Product Details
PA5-21928
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:3,000 | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:100-1:1,000 | - |
Immunocytochemistry (ICC/IF) |
1:100-1:1,000 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
Synthetic peptide corresponding to a region within amino acids 1 and 45 of Histone H2AZ |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.52 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
0.1M tris glycine, pH 7, with 10% glycerol |
Contains |
0.01% thimerosal |
Storage conditions |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_11154997 |
Product Specific Information
Recommended positive controls: Jurkat.
Predicted reactivity: Mouse (100%), Rat (100%), Dog (100%), Pig (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 11ac; H2A histone family, member V; H2A histone family, member Z; H2A.F/Z; H2A.Z variant histone 2; H2A.ZK5; H2A.ZK5ac; H2A/z; H2AFZac; H2AZ histone; H2AZK11ac; H2AZK7ac; histone H2A.F/Z; Histone H2A.V; Histone H2A.Z; purine-rich binding element protein B
Gene Aliases: H2A.z; H2A.Z-1; H2A.Z-2; H2A/z; H2AFV; H2AFZ; H2AV; H2AZ; H2AZ1; H2AZ2
UniProt ID: (Human) Q71UI9, (Human) P0C0S5
Entrez Gene ID: (Human) 94239, (Human) 3015
Molecular Function:
histone
molecular_function
DNA binding
protein heterodimerization activity
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
protein binding
chromatin DNA binding
nucleosomal DNA binding
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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